![]() ![]() ![]() 1, 3 Hemolysis has been recognized as the most frequent pre-analytical artefact encountered in laboratory specimens. In vitro is the most undesirable precondition that influences the accuracy of the results and dependability of laboratory testing. In vivo hemolysis is a result of a number of circumstances and diseases (inherited or acquired hemolytic anemias), whereas in vitro is triggered by improper or mishandled procedures during specimen collection. ![]() 1, 2 Hemolysis may occur in vivo and in vitro. Hemolysis is conventionally defined as the release of hemoglobin and other intracellular components of erythrocytes into the extracellular space of blood. ![]()
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